中文介绍： BMS-1001 是一种有效的 PD-1/PD-L1 相互作用的抑制剂，EC50值为253 nM。BMS-1001 可减轻可溶性PD-L1对T细胞受体介导的T淋巴细胞活化的抑制作用。 Information BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Targets PD-1/PD-L1 (Cell-free assay) 253 nM(EC50) In vitro BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. Cell Research(from reference) Cell lines：PD-L1 + aAPC/CHO-K1 cells (aAPCs), PD-1 Effector Cells (ECs) Concentrations：0.12 μM, 0.3 μM, 1.2 μM, 3 μM Incubation Time：24 h
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BMS-1001
CAS number：2113650-03-4 molecular formula：C35H34N2O7
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Specs
| Chinese alias | - | ||
| English alias | D-Serine,N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]- | ||
| CAS number | 2113650-03-4 | molecular formula | C35H34N2O7 |
| molecular weight | 594.65 g/mol | Exact mass | ≥98% |
| PSA | 130.000 Ų | logp | 3.03 |
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