Information MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. Targets NLRP3 (BMDM-based assay); NLRP3 (HMDM-based assay) 7.5 nM; 8.1 nM In vitro MCC950 is a potent, selective, small molecule inhibitor of NLRP3. MCC950 blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. MCC950 is active in ex vivo samples from individuals with Muckle-Wells syndrome. MCC950 reduces Interleukin-1p (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS. Cell Research(from reference) Cell lines：BMDM, HMDM, PBMC, HEK293T cells Concentrations：0.001 μM–10 μM, 5 nM–1000 nM Incubation Time：30 min, 45 min
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MCC950
CAS number：210826-40-7 molecular formula：C20H24N2O5S
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| Chinese alias | - | ||
| English alias | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | CRID3 | CP-456,773 | 6RS86E2BWQ | ||
| CAS number | 210826-40-7 | molecular formula | C20H24N2O5S |
| molecular weight | 404.48 g/mol | Exact mass | - |
| PSA | 117.000 Ų | logp | 3.400 |
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