diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist. In Vitro The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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diABZI-C2-NH2
CAS number：2137975-93-8 molecular formula：C36H43N13O4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2137975-93-8 | molecular formula | C36H43N13O4 |
| molecular weight | 721.81 g/mol | Exact mass | ≥96% |
| PSA | - | logp | - |
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