NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE) , and suppresses triglyceride biosynthesis through the farnesol pathway. In Vitro NB-598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB-598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [ 14 C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
NB-598 Maleate
CAS number：155294-62-5 molecular formula：C31H35NO5S2
overview
compound introduction
Specs
| Chinese alias | NB-598 马来酸盐 | ||
| English alias | - | ||
| CAS number | 155294-62-5 | molecular formula | C31H35NO5S2 |
| molecular weight | 565.74 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
