IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4( IRAK4 ) inhibitor. In Vitro Lack of IRAK-4 impairs the production of proinflammatory mediators by macrophages and DCs in response to M. bovis and M. tuberculosis . IRAK-4 -/- cells stimulated with E. coli LPS display delayed activation kinetics of all signaling proteins analyzed, and exhibit dramatically reduced p65 phosphorylation. IRAK1/4 (20 μM) has an inhibitory effect on LPS mediated IL-6 production. IRAK1/4 inhibitor do not decrease p38 phosphorylation in AMs. Combination of IRAK1/4 and Rip2 inhibitors inhibits TLR2-mediated cytokine production in sarcoidosis PBMCs and AMs. IRAK4 is overexpressed and activated in T-ALL. IRAK4 mRNA level is elevated in T-ALL cells from patients compared with the levels detected in thymic T cells or T cells from peripheral blood. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo IRAK-4 -/- mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4 +/+ or IRAK-4 +/- mice. IRAK-4 -/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection . MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
IRAK inhibitor 4
CAS number：1012104-68-5 molecular formula：C33H35F3N6O3
overview
compound introduction
Specs
| Chinese alias | IRAK 抑制剂 4 | ||
| English alias | 1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide | HY-13278 | MS-30783 | IRAK inhibitor 4 trans | IRAK inhibitor 4 (trans) | IRAK inhibitor 4 | MS-30782 | NCGC00390557-01 | 1-(( | ||
| CAS number | 1012104-68-5 | molecular formula | C33H35F3N6O3 |
| molecular weight | 620.66 g/mol | Exact mass | ≥99% |
| PSA | 117.000 Ų | logp | 7.6 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
