CU-CPT17e is a potent multi- Toll-like receptor ( TLR ) agonist that activates TLR3 , TLR8 , and TLR9 . In Vitro CU-CPT17e shows strong NF-κB activation in TLR3, TLR8 and TLR9 HEK293 cells with EC 50 values of 4.80±0.73, 13.5±0.58 and 5.66±0.17 μM, respectively. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC 50 value of 4.8±0.7 μM. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. The induction of apoptosis by CU-CPT17e in HeLa cells is investigated. HeLa cells are cultured with increasing concentrations of CU-CPT17e or poly I:C or blank control (DMSO) for 24 h. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL. These results suggest that the antiproliferative activity of CU-CPT17e against HeLa cells might result from its ability to directly induce apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TLR3 TLR8 TLR9
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CU-CPT17e
CAS number：2109805-75-4 molecular formula：C27H24N2O8
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| Chinese alias | - | ||
| English alias | 6,7-bis[(4-nitrophenyl)methoxy]spiro[chromene-2,4'-oxane] | CU-CPT17e | CU-CPT-17e | HY-101929 | BCP29395 | Spiro[2H-1-benzopyran-2,4'-[4H]pyran], 2',3',5',6'-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]- | MS-29365 | 2109805-75-4 | DTXSID801118086 | AKOS04 | ||
| CAS number | 2109805-75-4 | molecular formula | C27H24N2O8 |
| molecular weight | 504.49 g/mol | Exact mass | ≥98% |
| PSA | 129.000 Ų | logp | 5 |
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