产品应用： 7-叠氮基-4-甲基香豆素（AzMC）是一种可用于检测硫化氢（H2S）的荧光探针。 在H2S存在下可选择性地还原芳族叠氮部分，产生荧光7-氨基-4-甲基香豆素（AMC）以及在λex = 365nm和λem = 450nm处的荧光增加。该探针既可用于体外监测H2S的酶促产生，也可用于观察细胞中的H2S。该探针对H2S具有高度的敏感性和选择性，可在体外利用10μM探针提供200nm – 100μM H2S的线性检测范围，并在mM浓度的半胱氨酸、同型半胱氨酸、谷胱甘肽和多种其他常见的生物分析物的存在下选择性地与H2S进行反应。 Product Application: 7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H|2|S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H|2|S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with λex = 365 nm and λem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine β-synthase (CBS) inhibitors and activators.
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7-Azido-4-methylcoumarin
CAS number：95633-27-5 molecular formula：C10H7N3O2
overview
compound introduction
Specs
| Chinese alias | 羟甲香豆素杂质4 | ||
| English alias | 4-Methyl-7-azidocoumarin | 7-Azido-4-methyl-2H-1-benzopyran-2-one | AzMC | ||
| CAS number | 95633-27-5 | molecular formula | C10H7N3O2 |
| molecular weight | 201.18 g/mol | Exact mass | ≥98% |
| PSA | 40.700 Ų | logp | 3.2 |
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95633-27-5 | 7-Azido-4-Methylcoumarin.pdf
