TT-012 特异性结合动态MITF,并破坏后者的二聚体形成和 DNA 结合能力。TT-012 抑制 B16F10 黑色素瘤细胞中 MITF 的转录活性。TT-012抑制高MITF黑色素瘤细胞的生长,在动物模型中抑制肿瘤生长和转移,对肝脏和免疫细胞具有可耐受的毒性。
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(E)-3-(furan-2-yl)-N-[6-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]pyridin-2-yl]prop-2-enamide
CAS number:1164471-33-3 molecular formula:C19H15N3O4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1164471-33-3 | molecular formula | C19H15N3O4 |
| molecular weight | 349.3 g/mol | Exact mass | ≥99% |
| PSA | 97.400 Ų | logp | 2.2 |
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