α间抑制剂蛋白（IaIp）-包括α间胰蛋白酶抑制剂（IaI）和前α抑制剂（Pal），分子量分别为225 kDa和125 kDa。这些蛋白质在血浆中的浓度约为50mg/100ml。这些蛋白质的抑制活性是IAIP常见轻链bikunin的功能。 在急性炎症中，lal充当阴性急性期蛋白，而Pal充当阳性急性期蛋白。IaIp被认为是转移性疾病、感染性休克和补体系统疾病的生物标志物和生物疗法。 活性：当使用Na-苯甲酰基-L-精氨酸-对硝基苯胺盐酸盐（L-BAPNA）作为底物，用活性位点滴定的猪胰蛋白酶进行测试时，显示出抑制活性。 免疫印迹：与抗Bikunin免疫反应 由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。 用于研究用途或用于进一步制造。 Inter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of the proteins is a function of bikunin, the common light chain of the IAIP. In acute inflammation, the lal acts as a negative acute-phase protein, whereas the Pal acts as a positive acute-phase protein. IaIp are being considered as biomarkers and biotherapies for metastatic disease, septic shock and complement system disorders. Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate. Immunoblotting: Immunoreactive with anti-Bikunin Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. For research use or for use in further manufacturing.
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α间抑制蛋白(IaIp),人血浆
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | ≥90%(SDS-PAGE) |
| PSA | - | logp | - |
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