C-反应蛋白，人血浆

C-反应蛋白（CRP）是一种单体大小约为24kDa的同源五聚体蛋白。它是五聚蛋白家族的成员，五聚蛋白是一个蛋白质家族，其特征是钙依赖性配体结合和独特的环状结构。与许多其他五聚蛋白一样，CRP在对组织损伤、感染和全身炎症等身体损伤的急性期反应中高度上调。在正常的健康个体中，血液中CRP的浓度约为5mg/ml。这一数字在感染或其他炎症原因下会上升5-10倍。在严重的情况下，CRP水平可能会上升到200mg/L以上。 CRP可以用作一般炎症或更具体问题的生物标志物，如某些癌症、糖尿病、高血压、心血管疾病（CVD）或类风湿性关节炎（RA）。在细胞/分子水平上，CRP通过与死亡/垂死细胞或外来/入侵细菌上的表面分子结合来激活免疫反应的补体系统。研究上述疾病、补体系统诱导或急性期的实验室和公司会发现我们的CRP是他们研究中有用的试剂。 C-Reactive Protein (CRP) is a homopentameric protein with a monomer size of ~24 kDa. It is a member of the pentraxin family, a family of proteins characterized by their calcium dependent ligand binding and unique ring-like structure. Like many other pentraxins, CRP is highly upregulated in the acute-phase response to bodily insults such as tissue injuries, infections and general inflammation. In normal, healthy individuals the concentration of CRP in blood is ~5 mg/ml. This number rises 5-10 fold in response to infection or other causes of inflammation. In severe cases, CRP levels can rise above 200 mg/L. CRP can be used as a biomarker for general inflammation or more specific issues such as certain cancers, diabetes, hypertension, cardiovascular disease (CVD) or Rheumatoid Arthritis (RA). On a cellular/molecular level, CRP activates the complement system of the immune response by binding to surface molecules on dead/dying cells or foreign/invading bacteria. Laboratories and companies investigating the diseases mentioned, complement system induction or the acute phase would find our CRP a useful reagent in their studies. Ref.: Du Clos, T.W. 2000. Annals of Medicine. 4, 274-278.

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