Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO - ) , with an IC 50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC 50 value of 71.99 μM for ONOO - . Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor In Vitro Flazin significantly decreases cellular triglyceride (TG) by 12.0-22.4% compared with modeling groups and improved the TG and free fatty acid profile. Flazin efficiently reduces both cellular neutral lipid content by 17.4-53.9% and lipid droplets size by 10.0-35.3%. Flazin exhibits xanthine oxidase inhibitory with an IC 50 of 0.51 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 85.31 μM (BSA), 0.51 mM (XOD),EC 50 : 71.99 μM (ONOO - )
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Flazin
CAS number：100041-05-2 molecular formula：C17H12N2O4
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| Chinese alias | 弗拉津 | ||
| English alias | 1-[5-(hydroxymethyl)-2-furyl]-9H-pyrido[3,4-b]indole-3-carboxylic acid | EX-A5451 | USBWYUYKHHILLZ-UHFFFAOYSA-N | HY-141508 | InChI=1/C17H12N2O4/c20-8-9-5-6-14(23-9)16-15-11(7-13(19-16)17(21)22)10-3-1-2-4-12(10)18-15/h1-7,18,20H,8H2,(H,21,22) | DTXSID2014 | ||
| CAS number | 100041-05-2 | molecular formula | C17H12N2O4 |
| molecular weight | 308.29 g/mol | Exact mass | - |
| PSA | 99.400 Ų | logp | 2.1 |
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