Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level. In Vitro Honokiol DCA (20-40 μM; 24-48 h) inhibits the viability of LNCaP and C4-2 cells in a dose-and time-dependent manner. Honokiol DCA (5-20 μM; 10 days) inhibits clonogenicity of prostate cancer cells. Honokiol DCA (20-40 μM; 24-48 h) significantly decreases the level of androgen receptor (AR) and prostate specific antigen (PSA) protein in LNCaP cells. Honokiol DCA (40 μM; 24 h) significantly decreases AR promoter activity in LNCaP and C4-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Honokiol类似物 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Honokiol DCA
CAS number：1620160-42-0(DMSO) molecular formula：C22H18Cl4O4
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| Chinese alias | 和厚朴酚DCA | ||
| English alias | - | ||
| CAS number | 1620160-42-0(DMSO) | molecular formula | C22H18Cl4O4 |
| molecular weight | 488.19 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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