compound introduction
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM. In Vivo CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CDK8 3 nM (IC 50 )
