RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT . In Vitro RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
RP 70676
CAS number：136609-26-2(DMSO) molecular formula：C25H28N4S
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 136609-26-2(DMSO) | molecular formula | C25H28N4S |
| molecular weight | 416.58 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
