compound introduction
Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier In Vivo In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.37 nM (PDE10A)
