PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain ( K d =4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity In Vivo PHT-7.3 (200 mg/kg; i.p.; daily; for 20 days) exhibits cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female NOD-SCID mice (mut-KRas A549 NSCLC xenografts, mut-KRas H441 NSCLC xenografts) Dosage: 200 mg/kg Administration: Intraperitoneal injection, daily, for 20 days Result: Exhibited cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft . IC50& Target:Cnk1 PH-domain
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PHT-7.3
CAS number：1614225-93-2(DMSO) molecular formula：C24H23N3O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1614225-93-2(DMSO) | molecular formula | C24H23N3O3S |
| molecular weight | 433.52 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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