HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro In Vitro HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC 50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC 50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM. Additionally, upon infection of human HEK 293 cells (CC 50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC 50 values ranging from 3.9 to 12 µM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Flavivirus RNA dependent RNA polymerases (RdRp), SARS-CoV-2 RdRps>
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HeE1-2Tyr
CAS number：2245195-67-7(DMSO) molecular formula：C33H30N2O6S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2245195-67-7(DMSO) | molecular formula | C33H30N2O6S |
| molecular weight | 582.67 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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