compound introduction
CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s disease In Vitro CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:HDAC1 673 nM (IC 50 , 30 min (time-dependent)) PDE5 114 nM nM (IC 50 )
