WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX In Vitro WEHI-9625 (0-10 µM; Mcl1 −/− Bax −/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax −/− , but not Bak −/− , cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mcl1 −/− Bax −/− MEFs cells with ABT-737-pretreated Concentration: 0-10 µM Incubation Time: Result: Could prevent cell death. In Vivo WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Bak Bax
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WEHI-9625
CAS number：2595314-46-6(DMSO) molecular formula：C34H27NO5S2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2595314-46-6(DMSO) | molecular formula | C34H27NO5S2 |
| molecular weight | 593.71 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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