AMPK-IN-3

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC 50 s of 60.7, 107 and 3820 nM for AMPK (α2) , AMPK (α1) and KDR , respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer In Vitro AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively. AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 µM; 2 h) decreases the level of p-ACC in K562 cells. AMPK-IN-3 (1-100 µM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: K562 cells Concentration: 0.195313, 0.78125, 3.125, 12.5, 50 µM Incubation Time: 2 h Result: Decreased cellular levels of p-ACC(Ser79) in K562 cells. Cell Viability AssayCell Line: K562 cells Concentration: 1-100 µM Incubation Time: 24, 48, 72 h Result: Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours. Form:Solid IC50& Target:AMPK (α2) 60.7 nM (IC 50 ) AMPK (α1) 107 nM (IC 50 ) KDR 3820 nM (IC 50 )

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