NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) ( HY-125033 ) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV). In Vitro Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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NHC-diphosphate
CAS number：39023-73-9 molecular formula：C9H15N3O12P2
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| Chinese alias | NHC-二磷酸 | ||
| English alias | - | ||
| CAS number | 39023-73-9 | molecular formula | C9H15N3O12P2 |
| molecular weight | 419.18 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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