PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC 50 of 16.1 nM; PF-2771 is used as an anticancer agent. In Vitro PF-2771 is a potent and selective CENP-E inhibitor, inhibiting CENP-E motor activity with an IC 50 of 16.1 nM. PF-2771 shows no inhibitory effect on the ATPase activities of highly related kinesins (0% inhibition of Eg5/KSP, chromokinesin, and MCAK at both 1 or 10 μM PF-2771). PF-2771 exhibits inactive activity against 74 protein kinases (all 5 μM). PF-2771 (100 nM) reusults in a chromosomal congression defect in MDA-MB-468 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-2771 (100 mg/kg, every day i.p.) potently inhibits CENP-E motor function, and causes tumor regression in SCID mice bearing AA1077 mammary tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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PF-2771
CAS number：2070009-55-9(DMSO) molecular formula：C29H36ClN5O4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2070009-55-9(DMSO) | molecular formula | C29H36ClN5O4 |
| molecular weight | 554.08 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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