GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC 50 of 7.9. In Vitro Results from [ 3 H]-PGE 2 binding assay in CHO cells overexpressing the human EP 1 receptor demonstrate that GSK-269984A is an antagonist of EP 1 receptor with a pIC 50 of 7.9. GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE 2 dose-response curve and Schild analysis shows that GSK-269984A is a competitive antagonist with pA 2 8.1±0.3 and slope 1.0. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GSK-269984A demonstrates an ED 50 of 2.6 mg/kg (po), with the 10 mg/kg dose showing equivalent reversal of hypersensitivity to the standard. GSK-269984A displays moderate blood clearance in the rat and dog and high clearance in the monkey which is reflected in the half-life for each species . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EP1 7.9 (pIC 50 )
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
GSK-269984A
CAS number：892664-04-9 molecular formula：C20H14Cl2FNNaO3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Q27280309 | GSK269984A | GSK-269984A | 2-Pyridinecarboxylic acid, 6-((5-chloro-2-((4-chloro-2-fluorophenyl)methoxy)phenyl)methyl)-, sodium salt (1:1) | Sodium 6-((5-chloro-2-(((4-chloro-2-fluorophenyl)methyl)oxy)phenyl)methyl)-2-pyridinecarboxylate | UNII | ||
| CAS number | 892664-04-9 | molecular formula | C20H14Cl2FNNaO3 |
| molecular weight | 429.22 g/mol | Exact mass | ≥99% |
| PSA | 62.300 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
