F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress In Vitro F13714 targets 5-HT1A autoreceptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels . F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5% . F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement . F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:5-HT 1A Receptor
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F 13714 fumarate
CAS number：208109-39-1 molecular formula：C25H29ClF2N4O5
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| Chinese alias | F 13714 富马酸盐 | ||
| English alias | - | ||
| CAS number | 208109-39-1 | molecular formula | C25H29ClF2N4O5 |
| molecular weight | 538.97 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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