Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 . In Vitro Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC 50 95 nM vs. MS-275 EC 50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)
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Corin
CAS number：1808113-09-8(DMSO) molecular formula：C26H28N4O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1808113-09-8(DMSO) | molecular formula | C26H28N4O2 |
| molecular weight | 428.53 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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