BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42 . In Vitro BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18 F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t 1/2 =24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [ 18 F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.4 nM (Aβ1-42)
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BF-168
CAS number：634911-47-0 molecular formula：C18H17FN2O2
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| Chinese alias | - | ||
| English alias | HY-112830 | BF 168 | BF-168 | 6-(2-fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole | SCHEMBL989597 | 4-[(E)-2-[6-(2-Fluoroethoxy)-1,3-benzoxazol-2-yl]ethenyl]-N-methylaniline | 6-(2-fluoroethoxy)-2-[2-(4-methylaminophenyl)ethenyl] benzo-xazole | ||
| CAS number | 634911-47-0 | molecular formula | C18H17FN2O2 |
| molecular weight | 312.34 g/mol | Exact mass | ≥99% |
| PSA | 47.300 Ų | logp | 4.4 |
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