SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease In Vitro SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Swiss Webster mice (20-25 g). Dosage: 5-20 mg/kg Administration: I.p. Result: Significantly attenuated the 5-CT-induced hypothermia. IC50& Target:5-HT 7 Receptor 7.5 (pKi)
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SB 258719
CAS number：195199-95-2(DMSO) molecular formula：C18H30N2O2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 195199-95-2(DMSO) | molecular formula | C18H30N2O2S |
| molecular weight | 338.51 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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