compound introduction
GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3 , with a K i of 14 nM and an IC 50 of 130 nM In Vitro A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (K i =14±6 nM and 345±36 nM, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SMYD3|14 nM (Ki)|SMYD3|130 nM (IC|50|)
