compound introduction
AZ506 is a potent SMYD2 inhibitor with an IC 50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal In Vitro AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC 50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC 50 of 2.43 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SMYD2 17 nM (IC 50 )
