Amelubant (BIIL 284) 是一种有效、长效的 LTB4 receptor 拮抗剂，对 LTB4 受体的结合亲和性很低，在细胞和细胞膜中，Ki 值分别为 221 nM 和 230 nM。Amelubant (BIIL 284) 是活性代谢物 BIIL 260 和 BIIL 315 的前体。具有抗炎活性。 Amelubant (BIIL 284) is a potent, oral and long acting LTB 4 receptor antagonist, negligibly binds to LTB 4 receptor, with K i s of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity In Vitro Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB 4 receptor antagonists, with K i s of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:LTB 4 221 nM (Ki, in vital human granulocytes) LTB 4 230 nM (Ki, in cell membranes)
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Amelubant
CAS number：346735-24-8(DMSO) molecular formula：C33H34N2O5
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| Chinese alias | 阿梅卢班特 | ||
| English alias | - | ||
| CAS number | 346735-24-8(DMSO) | molecular formula | C33H34N2O5 |
| molecular weight | 538.63 g/mol | Exact mass | - |
| PSA | - | logp | - |
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