p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM In Vitro p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain. Form:Solid IC50& Target:Ki: 32.6 μM (TPH)
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p-Ethynylphenylalanine
CAS number：278605-15-5 molecular formula：C11H11NO2
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| Chinese alias | 对乙炔基苯丙氨酸 | ||
| English alias | MS-23023 | (S)-2-Amino-3-(4-ethynylphenyl)propanoic acid | EN300-2677165 | (2S)-2-amino-3-(4-ethynylphenyl)propanoic acid | p-ethynylphenylalanine | SCHEMBL93953 | DTXSID70649147 | (S)-2-Amino-3-(4-ethynylphenyl)propanoicacid | Q27455671 | HY-23460 | 4-Et | ||
| CAS number | 278605-15-5 | molecular formula | C11H11NO2 |
| molecular weight | 189.21 g/mol | Exact mass | ≥99% |
| PSA | 63.300 Ų | logp | -1.300 |
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