compound introduction
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC 50 of 3.6 nM. In Vitro PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC 50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and Form:Solid IC50& Target:PI4KIIIβ 3.6 nM (IC 50 ) PI4KIIIα 3 μM (IC 50 ) PI3Kδ 720 nM (IC 50 ) PI3KC2γ 1 μM (IC 50 ) PI3Kα 10 μM (IC 50 ) PI3Kγ 20 μM (IC 50 )
