MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97 . MSC1094308 can be used in study of cancer In Vitro MSC1094308 (10 µM; 8 h) induces accumulation of polyubiquitin as a biomarker for degradation inhibition in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HCT116 cells Concentration: 10 µM Incubation Time: 8 h Result: Led to accumulation of polyubiquitinated proteins (a biomarker for degradation inhibition). Form:Solid IC50& Target:IC50: 0.71 μM (VPS4B), 7.2 μM (p97)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
MSC1094308
CAS number：2219320-08-6 molecular formula：C29H29F3N2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2219320-08-6 | molecular formula | C29H29F3N2 |
| molecular weight | 462.5 g/mol | Exact mass | ≥99% |
| PSA | 27.800 Ų | logp | 7.000 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
