Dexelvucitabine (Reverset; d-d4FC), a Cytidine analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent In Vivo Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t 1/2α and t 1/2β , respectively) of 0.7 and 3.6 h in monkeys, respectively. The C max ranges from 21.1 to 47.5 μM. Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively) in woodchucks. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HIV-1
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Dexelvucitabine
CAS number：134379-77-4 molecular formula：C9H10FN3O3
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| Chinese alias | 右旋卡西他滨 | ||
| English alias | 2',3'-Dideoxy-2',3'-didehydro-beta-L-5-fluorocytidine | INCB-8721 | KU8SPJ271W | CYTIDINE, 2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUORO | Cytidine, 2',3'-didehydro-2',3'-dideoxy-5-fluoro- | 4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyr | ||
| CAS number | 134379-77-4 | molecular formula | C9H10FN3O3 |
| molecular weight | 227.19 g/mol | Exact mass | ≥99% |
| PSA | 88.200 Ų | logp | -1.3 |
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