Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A ( KDM1A / LSD1 ) inhibitor. In Vitro Iadademstat dihydrochloride is a KDM1A inhibitor that inactivate KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. Iadademstat has very high selectivity for KDM1A over the MAO enzymes, high selectivity over KDM1B and unrivaled subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines. Iadademstat provokes a time and dose-dependent induction of the Cd11b differentiation marker in MLL-AF9 cells, which interestingly preceeds changes in H3K4me2 levels. While MLL-translocated cells are especially sensitive, other acute leukemia (AL) cell lines also respond to Iadademstat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:KDM1A/LSD1
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Iadademstat dihydrochloride
CAS number：1431303-72-8 molecular formula：C15H24Cl2N2
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| Chinese alias | 盐酸伊达地司他 | ||
| English alias | 1431326-61-2 | MS-24378 | N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride | ORY 1001 | Iadademstat (dihydrochloride) | AKOS027326828 | ORY-1001(trans) | A901235 | LSD1-IN-1 | 1431303-72-8 | HY-12782 | Iadademstat dihydrochloride | | ||
| CAS number | 1431303-72-8 | molecular formula | C15H24Cl2N2 |
| molecular weight | 303.27 g/mol | Exact mass | ≥99% |
| PSA | 38.100 Ų | logp | - |
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