Clopidogrel thiolactone is an active metabolites containing thiols resulting from thionolactone transformation of clopidogrel . Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent In Vivo Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) has good biological availability and pharmacokinetic parameters . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley male rats Dosage: 8 μm/kg; orally clopidogrel (24 μm/kg) Administration: Intravenous injection; collected blood at 0 h (before dosing) and 0.083, 0.167, 0.5, 1, 2, 4, 6, 8, 24 h postdose. Result: 1.19 Parameter Clopidogrel C max (μg/L) 6.93 T max (h) 0.583 t 1/2 (h) 2.48 AUC 0-∞ (μg*h/L) 32.2 Form:Solid IC50& Target:P2Y12 Receptor
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Clopidogrel thiolactone
CAS number：1147350-75-1 molecular formula：C16H16ClNO3S
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| Chinese alias | 氯吡格雷硫内酯 | ||
| English alias | - | ||
| CAS number | 1147350-75-1 | molecular formula | C16H16ClNO3S |
| molecular weight | 337.82 g/mol | Exact mass | ≥98% |
| PSA | 71.900 Ų | logp | 2.600 |
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