JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR) , blocking the κ-agonist U50, 488-induced antinociception. In Vivo JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine . JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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JDTic dihydrochloride
CAS number：785835-79-2 molecular formula：C28H41Cl2N3O3
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| Chinese alias | JDTic 二盐酸盐 | ||
| English alias | F84481 | 785835-79-2 (HCl) | JDTic 2HCl | (3R)-7-Hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide--hydrogen chloride (1/2) | 3-Isoquinolinecarboxamide, 1,2,3,4-tetr | ||
| CAS number | 785835-79-2 | molecular formula | C28H41Cl2N3O3 |
| molecular weight | 538.55 g/mol | Exact mass | ≥99% |
| PSA | 84.800 Ų | logp | - |
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