RAS inhibitor Abd-7, a potent RAS-binding compound ( K d =51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K , CRAF and RALGDS as well as NRAS Q61H and HRAS G12V. In Vitro RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: DLD-1 cells, HT1080 cells Concentration: 0-20 μM Incubation Time: 24-48 hours Result: The IC 50 of 8 μM in DLD-1 and 10 μM in HT1080 at 72 h (similar values for the IC 50 were found after 48 h). Form:Solid
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RAS inhibitor Abd-7
CAS number：2351843-48-4 molecular formula：C23H25N3O3
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| Chinese alias | RAS 抑制剂 Abd-7 | ||
| English alias | - | ||
| CAS number | 2351843-48-4 | molecular formula | C23H25N3O3 |
| molecular weight | 391.46 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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