Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC 50 s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis In Vitro Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration: 5, 10, and 20 μM Incubation Time: 4 days Result: Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells. In Vivo Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6- to 8-week-old female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage: 400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration: Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result: Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. Form:Solid IC50& Target:MALT1
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Mepazine hydrochloride
CAS number：2975-36-2 molecular formula：C19H23ClN2S
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| Chinese alias | 盐酸美帕嗪 | ||
| English alias | BENZOTHIAZOLE, 1-(P-AMINOPHENYL)-5-METHYL- | NSC64076 | NSC-64076 | Q27289984 | (Acetyloxy)(5-nitro-2-furyl)methyl acetate # | EINECS 221-020-8 | 10-((1-Methyl-3-piperidyl)methyl)phenothiazine hydrochloride | 10H-PHENOTHIAZINE, 10-((1-METHYL-3-PIPERIDINYL | ||
| CAS number | 2975-36-2 | molecular formula | C19H23ClN2S |
| molecular weight | 346.92 g/mol | Exact mass | ≥99% |
| PSA | 31.800 Ų | logp | - |
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