GSK2983559 is an orally active and potent receptor interacting protein 2 ( RIP2 ) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples. Appearance:Solid IC50& Target:RIPK2 In Vitro:GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells Concentration: 1-1024 nM Incubation Ti In Vivo:GSK2983559 (oral gavage; 3 and 10mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice (female) injected with MDP (100 Biological Activity:GSK2983559 is an orally active and potent receptor interacting protein 2 ( RIP2 ) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
GSK2983559
CAS number：unknown molecular formula：C21H28CaN4O10PS2+
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H28CaN4O10PS2+ |
| molecular weight | 611.61 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
