Ivaltinostat (CG-200745) formic is an orally active, potent pan- HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic Appearance:Oil IC50& Target:HDAC In Vitro:Ivaltinostat (CG-200745; 0.01-100 μM; 48 hours) formic inhibits growth of prostate cancer cells (LNCaP, DU145 and PC3 cells). Ivaltinostat (1, 10 μM; 24, 48 hours) formic increases sub-G1 population, and activates caspase-9, -3 and -8. Ivaltinostat ( In Vivo:Ivaltinostat (CG-200745; p.o.; 30mg/kg/day; for 7 days) formic attenuates oxidative stress, inflammatory cytokines, and adhesion molecules in UUO kidneys. MCE has not independently confirmed the accuracy of these methods. They are for reference only Biological Activity:Ivaltinostat (CG-200745) formic is an orally active, potent pan- HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic
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Ivaltinostat formic
CAS number：unknown molecular formula：C25H35N3O6
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| Chinese alias | 伊伐替司他甲酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C25H35N3O6 |
| molecular weight | 473.56 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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