compound introduction
HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC 50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. IC50& Target:HDAC10 58 ± 10 nM (IC 50 ) hHDAC8 920 ± 170 nM (IC 50 ) hHDAC6 2420 ± 530 nM (IC 50 ) Biological Activity:HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC 50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.
