iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice Appearance:Solid In Vitro:iMDK (50-500 nM) quarterhydrate suppressed AKT phosphorylation in a dose-dependent manner in H441 lung adenocarcinoma cells after treatment for 72 h. In contrast, iMDK quarterhydrate robustly increases p-ERK. MCE has not independently confirmed the a In Vivo:The combination treatment of iMDK ( (9mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model. MCE has not independently confirmed the accuracy Biological Activity:iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
iMDK quarterhydrate
CAS number：unknown molecular formula：C21H13FN2O2S.1/4H20
overview
compound introduction
Specs
| Chinese alias | iMDK 四分之一水合物 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H13FN2O2S.1/4H20 |
| molecular weight | 380.91 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
