TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication . TMC647055 Choline salt has potent HCV combine activity with an IC 50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus Appearance:Solid IC50& Target:EC90: 0.3 μM (Huh7-Luc cell) . EC50: 82 nM (HCV) In Vitro:TMC647055 (Choline salt) has antiviral activity with an EC 90 value of 0.3 μM in Huh7-Luc cells. TMC647055 Choline salt has potent combine activity with an EC 50 value of 82 nM in cellular HCV assays. MCE has not independently confirmed the accu In Vivo:TMC647055 Choline salt (compound 18a) (2mg/kg, iv.; 1mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10mg/kg, combined with a moderate plasma clearanceand low Biological Activity:TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication . TMC647055 Choline salt has potent HCV combine activity with an IC 50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus
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TMC647055 Choline salt
CAS number：unknown molecular formula：C37H53N5O8S
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| Chinese alias | TMC647055 胆碱盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C37H53N5O8S |
| molecular weight | 727.91 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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