BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [ 125 I]PYY 3-36 . BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAP Appearance:Solid In Vitro:BIIE-0246 hydrochloride (1 µM; 24 h) decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated (10, 100 ng/mL) in mouse podocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. We In Vivo:BIIE-0246 hydrochloride (1.3mg/kg; I.p.; daily for 2 or 4.5 weeks) prevents diet-induced obesity in OE-NPYDβH mice, but enhances obesity in WT Mice. BIIE-0246 hydrochloride (10 µg/day; i.p.; daily for 14 days) reduces albuminuria in ADR (adriamycin) Biological Activity:BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [ 125 I]PYY 3-36 . BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAP
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BIIE-0246 hydrochloride
CAS number：unknown molecular formula：C49H57N11O6.xHCl
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| Chinese alias | BIIE-0246 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C49H57N11O6.xHCl |
| molecular weight | - | Exact mass | ≥99% |
| PSA | - | logp | - |
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