HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC 50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC 50 of 108 nM in human peripheral blood mononuclear cells (PBMCs). IC50& Target:HPK1 0.25 nM (IC 50 ) In Vitro:HPK1-IN-3 (compound 27; 0.25-4 μM; 24-h) treatment shows a statistically significant elevation of proinflammatory cytokines IL-6 and TNF-α was observed in a concentration-dependent manner in human monocyte-derived dendritic cells. MCE has not indepen Biological Activity:HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC 50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC 50 of 108 nM in human peripheral blood mononuclear cells (PBMCs).
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HPK1-IN-3
CAS number：unknown molecular formula：C23H22F4N6O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C23H22F4N6O2 |
| molecular weight | 490.45 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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