compound introduction
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase ( LMW-PTP ) inhibitor ( IC 50 =4 nM, K i =1.2 nM). SPAA-52 can be used in diabete research. Appearance:Solid IC50& Target:IC 50 : 4 nM (LMW-PTP) In Vivo:1.19 Plasma PK Parameters in Healthy MiceCompound SPAA-52 dose route 2mg/kg IV 10mg/kg PO AUC (0−8 h) (nM h) 15,100 37,300 C 0 or C max (nM) 13,400 9690 C 0 or C max unbound (nM) 332 233 Vd ss (L/kg) 0.42 CL (mL/min/kg) 5.65 T 1/2 (h) 1.41 4.2 F (% Biological Activity:SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase ( LMW-PTP ) inhibitor ( IC 50 =4 nM, K i =1.2 nM). SPAA-52 can be used in diabete research.
