SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet Appearance:Solid IC50& Target:IC 50 : 42 nM (TAO3), 237 nM (MEKK3) In Vitro:SBI-581 shows moderate selectivity (> 5-10x) against the majority of a broad panel of kinases. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:SBI-581 (10mg/kg, IP, once) displays reasonable pharmacokinetics (t 1/2 =1.5 hr; AUC= 1202 hr*ng/mL; Cmax= ~2 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet
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SBI-581
CAS number：unknown molecular formula：C24H21N3O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C24H21N3O2 |
| molecular weight | 383.44 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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