GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC 50 of 0.28 μM. Appearance:Solid IC50& Target:PAR2 In Vitro:In an intracellular Ca 2+ (iCa 2+ ) mobilization assay using HT29 colon cancer cells, GB110 (EC 50 240±20 nM; pEC 50 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC 50 210±30 nM; pEC 50 6.6±0.05), 10-fold more potent than SLIGRL-NH2, bu Biological Activity:GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC 50 of 0.28 μM.
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GB-110 hydrochloride
CAS number：unknown molecular formula：C33H49ClN6O5
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| Chinese alias | GB-110盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C33H49ClN6O5 |
| molecular weight | 645.23 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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