KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 In Vitro KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE 2 in mouse osteoblastic cells. KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC 50 ~1.2 μM ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: male Sprague-Dawley rats (5-week-old) . Dosage: 1, 3, 10, and 30 mg/kg. Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days. Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg. Form:Solid IC50& Target:Prostaglandin Receptor
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KW-8232 free base
CAS number：170365-25-0 molecular formula：C36H37ClN4O3
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| Chinese alias | KW-8232自由基 | ||
| English alias | Kw 8232 | SCHEMBL9079942 | HY-100304 | Piperazine, 1-((3-(bis(4-hydroxyphenyl)methyl)-1-(2-(dimethylamino)ethyl)-1H-indol-2-yl)carbonyl)-4-(2-chlorophenyl)- | BK177443 | MS-30686 | Methanone, (3-(bis(4-hydroxyphenyl)methyl)-1-(2-(dimethylamino)ethyl)-1H-i | ||
| CAS number | 170365-25-0 | molecular formula | C36H37ClN4O3 |
| molecular weight | 609.16 g/mol | Exact mass | ≥95% |
| PSA | 72.200 Ų | logp | 6.7 |
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